M026: QUINOLINE THERAPY IN CHILDREN WITH CYSTIC FIBROSIS
N Kapranov, YB Belousov, NY Kashyrskaya, EY Smirnova.
(Dept of Clinical Pharmacology, Medical Universitv of Russia,
Moscow CF Centre, Moscow, Russia)
Forty-one patients with cystic fibrosis were studied. The age range was 3-16 and all had severe or very severe disease. All had some degree of respiratory failure and all had infection with pseudomonas aeruginosa.
For treatment purposes children were divided into 2 groups;
Group 1 - Ciprofloxacin Group (31 patients) - received Ciprofloxacin 20-30 mg/kg/day for 14-18 days. Pseudomonas was non mucoid in 21 patients, mucoid in 6 and mixed in 5;
Group 2 - Ofloxacin Group (9 patients) - all had non mucoid forms.
All children irrespective of antibiotic improved clinically.
Clinical eradication of non mucoid pseudomonas was only noted in 3 patients who had received Ciprofloxacin.
The clinical remission was much longer in the group receiving Ciprofloxacin than those receiving Ofloxacin.
Side effects included allergic skin reaction in 2 patients on Ciprofloxacin and one patient on Ofloxacin
Transient increase in SGOT and SGPT was noted in 10 patients on Ciprofloxacin and 4 on Ofloxacin.
Fluoroquinolone treatment by either Ciprofloxacin or Ofloxacin was shown to be clinically efficacious with only a low number of side effects.