M024: XANTHOMONAS MALTOPHILIA CHRONIC LUNG INFECTlON IN CF
PATIENTS: EPIDEMIOLOGY, ANTIBIOTICS SENSITIVITY, INFLUENCE ON
CLINICAL COURSE.
Piamaroli A.*,Marzano M.T.*,Levi R.*,Garlaschi L.**, Colombo
R**,Padoan R* *Cystic Fibrosis Center, Dept. of Pediatrics, University
of Milan. **laboratorio Ricerche Cliniche, Sez. Microbiologia,
Istituti Clinici di Perfezionamento, Milano
Ps. aeruginosa chronic lung infection is a frequent event in CF and it is associated with pulmonary deterioration. But B.cepacia or Alc. Xylosoxidans or X. Maltophilia, have also been recognised to colonize CF lung. Our aim was to study X Maltophilia respiratory tract infections in patients followed at Mllan CF Center.
140 Out Of 1442 different strains isolated since July to December '94 are X Maltophilia (9.7%)
Sputum cultures (performed in the last 3 months) from 342 patients (93% of our total population) showed that 52 patients (14.6%) harboured X.Maltophilia .
In the figure susceptibilities of Ps.aeruginosa (162 strains), X.Maltophilia (82 strains), Ps. Fluorescens-putida (28 strains) and B.cepacia (6 strains) to antibiotics are shown. It is noticeable the very low pattern of sensitivity of X Maltophilia strains, and that 44% of patients (23/52) harboured at Ieast. one multiresistant X. Maltophilia strain. Clinical study. FVC % of predicted was lower in 14 patients colonized with X Maltophilia when compared to patients without matched for sex and age (90.6 14.8% vs 105 125.%) together with serum IgG higher in X Maltophilia positive patients (1555 486 mg% vs 1387 + 252 mg
In conclusion: prevalence of X.Maltophilia is higher in our Center than previous reported from other CF Centers; X Maltophilia susceptibility to antibiotics is low, with a high frequency of multiresistant strains; further studies are needed to define the importance of X Maltophilia in determining clinical status and lung function CF patients.