M011: PSEUDOMONAS AERUGINOSA AND BURKHOLDERIA CEPACIA
INFECTION IN DANISH AND CANADIAN CYSTIC FIBROSIS PATENTS.
T. Kovesi*, M. Corey*, H. Levison* & N. Høiby (Department
of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark
and *Hospital for Sick Children, Toronto, Canada)
Two groups of CF patients, 302 from the Toronto Centre (median age: 15.8) and 214 from the Copenhagen Centre (median age: 15.5), were compared with respect to gender, prevalence of chronic Pseudomonas aeruginosa (PA) and Burkholderia cepacia (BC) lung infections, pulmonary function tests and development of PA and BC precipitins.
Among children and adolescents, the female to male ratio was highest in Copenhagen (52% vs. 46% for age below 10 years, 58% vs. 44% for age >10 and <18 years).
The PA prevalence was lower in children (p<0.03), but higher in adults (p<0.005) in Copenhagen, whereas the BC prevalence was much higher at all ages in Toronto (p<0.005).
Age % Prevalence of PA %Prevalence of PC (years) Copenhagen Toronto Copenhagen Toronto 0-10 13* 29 1.5* 4.5 11-20 66 73 7 35 2 1 -40 92 75 0 58
*Born after cohort isolation was introduced in 1981 in Copenhagen.
In both centres the number of PA arid BC precipitins increased with age in patients chronically infected with PA and BC, respectively.
In both groups of patients, the number of PA precipitins increased with declining lung function measured by FEV1% (Copenhagen: Rho=-0.44, p<0.001 Toronto: Rho=-0.20, p<0.001). There was no significant correlation between FEV 1% and BC precipitins.