M006: BURKHOLDERIA (PSEUDOMONAS) CEPACIA PULMONARY COLONIZATION
IN PATIENTS WITH CYSTIC FIBROSIS (CF): A TWO YEARS EPIDEMIOLOGICAL
FOLLOW-UP IN FRANCE
C.SEGONDS, E.BINGEN, G.COUETDIC, Y.MICHEL-BRIAND, G.CHABANON
and the French "Observatolre Burkholdena cepacia "
study group.
Epidemiological data were collected from 49 CF centers (2484 patients) for year 1993, and 56 centers (2949 patients) for year 1994.
- incidence and prevalence rates were respectively 0,7 and 1,7% in 1993; 0,8 and 2,1% in 1994.
- prevalence rates per center varied from 0 to 40%.
- a majority of centers (35/49 in 1993: 71%, 33/56 in 1994: 59%) did not report any case of colonization.
- new cases were reported in 1994 by 14 centers (< 2 in 13 centers, 10 in 1 center).
The patterns of colonization were retrospectively reviewed in 71 patients, mainly children (mean age: 14, range 2-29).
- 44/71 patients (62%) were persistently colonized.
- the mean age of B.cepacia acquisition was 12 (range <1-28).
- 56/71 patients (79%) also harboured Pseudomonas aeruginosa, the mean age of P.aeruginosa acquisition being 8 (range <1-23).
- B.cepacia acquisition was posterior to P.aeruginosa colonization in 43/56 patients (77%), prior to it in 3 (5%) and simultaneous in 10 (18%).
- the most frequently B.cepacia associated organisms beside P.aeruginosa were Staphylococcus aureus (3096) and Haemophilus influenzae (14%).
- only 56% of patients had received nebulised antibiotics (colistin and/or aminoglycosides).
CONCLUSION: No significant increase of B.cepacia prevalence emerged from this 1993-1994 study in France; nevertheless, high rates of colonization are observed in some CF centers. The chronological features of infection are similar to those descrihed in other countries.
This work was supported by the AFLM (Assoclation Francalse de Lutte onntre la Mucoviscidose).